Study finds connection between gut microbiome and bone density

low bone density increases the risk of developing osteoporosis, affecting more than 10 million Americans over the age of 50, and can increase the risk of fractures.

Titled “A Two-Cohort Study on the Association between the Gut Microbiota and Bone Density, Microarchitecture, and Strength,” the study found that bacteria called Akkermansia, which has been associated with obesity, and Clostridiales bacterium DTU089, had negative associations with bone health for older adults.

DTU089, a bacterium from the class, Clostridia, has been described to be more abundant in people with lower physical activity, and lower protein intake, and could be significant because prior studies have found protein intake and physical activity have a definite connection to skeletal health.

“We found patterns in which greater abundance of microbiota were associated with worse measures of bone density and microarchitecture. In fact, some bacteria were associated with differences in the bone cross sectional area, suggesting the possibility that certain microbes could influence how the bone changes size with aging,” said Dr. Kiel.

“It is premature to know if the bacterial organisms themselves may have effects on skeletal health. With additional studies we might be able to gain insights regarding associations between specific bacterial species in the intestine and skeletal integrity. We also hope to identify specific functional pathways influenced by the bacteria that could influence the skeleton.”

“For example, some bacteria can lead to low levels of inflammation that may affect bone health. Ultimately, if findings like this are confirmed, we may be able to target the gut microbiome to influence skeletal health.”

Provided by
Hebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research