Childhood trauma may heighten subsequent risk of pregnancy complications

Childhood trauma, such as abuse, emotional neglect, and exposure to domestic violence may heighten a woman’s subsequent risk of pregnancy complications, and of giving birth to a low birthweight or premature baby, finds a pooled data analysis of the available evidence, published in BMJ Open.

The risks of pregnancy related diabetes, high blood pressure, depression/anxiety and of giving birth to underweight and or premature babies may all be significantly higher, the analysis suggests. While previously published research suggests that early life trauma can have a major negative impact on health in adulthood, it’s not clear if this extends to pregnancy.

To explore this further, the researchers reviewed 32 relevant studies, published between 1994 and 2022. Three out of 4 were long-term (cohort) studies, with the remainder observational or comparative (case-control) studies.

Most (19) were carried out in the U.S.. The rest were from Canada (3), Europe (6), and other regions (4). Study participants ranged in number from 48 to 11,556.

Pooled data analysis of 21 studies showed that overall, women who had experienced some form of childhood trauma were 37% more likely to have pregnancy complications than those who hadn’t. They were also 31% more likely to give birth to underweight or premature babies.

Further in-depth analysis showed that childhood trauma was associated with a 39% heightened risk of pregnancy related diabetes, a 59% heightened risk of antenatal depression, a 27% heightened risk of giving birth to an underweight baby, and a 41% heightened risk of preterm delivery.

There could be several direct and indirect explanations for the findings, suggest the researchers.

Childhood trauma might alter regulation of stress signaling pathways and immune system function; it might also change brain structure and function; or it might speed up cellular aging, they say.

Previously published research suggests that it’s also associated with a greater likelihood of risky behaviors in adulthood, including substance misuse, physical inactivity, and poor diet, all of which may influence the risk of pregnancy complications and outcomes.

The researchers acknowledge that most of the included studies were from high-income western countries, so the findings may not generalizable elsewhere, nor were they able to assess the potential impact of different types of childhood trauma.

But they nevertheless conclude, “The results suggest that exposure to [childhood trauma] increases the risk of pregnancy complications and adverse pregnancy outcomes. The identification of women exposed to [these experiences] and personalizing their care may provide opportunities to improve maternal and child mental and physical health.”

They also emphasize, “Beyond screening for [childhood trauma], our findings emphasize the importance of preventing [these events] in children to reduce immediate impacts as well as intergenerational transmission.”