To learn more about the association between CD4+ T cells and glaucoma damage, the team gave test mice antibodies that prevented the cells from interacting with a protein known as MAdCAM-1, which led to a reduction in inflammation in the eye and damage to the retina.
The team concludes that in addition to linking gut immune cells to glaucoma damage, their study also highlights the role that the immune system can play in diseases such as glaucoma.
More information:
Chong He et al, Gut-licensed β7 + CD4 + T cells contribute to progressive retinal ganglion cell damage in glaucoma, Science Translational Medicine (2023). DOI: 10.1126/scitranslmed.adg1656
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Association found between gut immune cells and eye damage from glaucoma (2023, August 5)
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